Sporotrichosis: Review of Innate and Acquired Immune Mechanisms

Context: Different factors such as the site of infection, etiological agent, and immune system can modify antifungal response host. Differences in Sporothrix schenckii strains’ virulence host’s competency may be involved development sporotrichosis. Nevertheless, mechanisms related to disease’s progression remain not fully elucidated. Nowadays, no model outweighs usefulness mice biological studies. In these models, transient controlled immunity is created by depressed inflammatory cells during acute phase disease. This also nitric oxide-induced T-cell apoptosis lack a mitogen response. Evidence Acquisition: The recognition lipid components S. induce prolong inflammation. occurs mainly through Toll-like receptor (TLR)-4 or inflammasome. At same time, TLR-2-mediated identification fungal exoantigen serve an evasion process, continuing worsening infection. Cell-mediated have predominant influence on modulating clinical expression sporotrichosis, which Th1/Th17 immunity. Conclusions: this study, we aimed explore innate acquired well most commonly used animal models for experimental